ANAT 262 Lecture Notes - Lecture 9: Persistence Length, Depolymerization, Cell Membrane
30 Aug 2016
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Document Summary
Intermediate filaments form cross-strand, run across cell stability & strength. Microtubules from central organizing centre, creates polar coordinates, tracks for motor proteins to move along. Inherent filament dynamics: growing & shrinking of filaments. Growing & shrinking over time, originating from central organizing centre. Can reassemble at different sites instead of moving whole polymer. Bacteria as signal for actin rearrangement to push neutrophil. All cytoskeleton filaments are made of multiple protofilaments. Filamentous actin (polymer form) vs globular actin (soluble free form) Persistence length: how long will be straight for. Polar: one end looks structurally distinct from other end. Central organizing centre act as polar coordinates direction for movement. Actin & tubulin are enzymes: bind to & hydrolyze nucleotides as part of polymerization & depolymerisation cycles. * = high affinity addition site; next addition can make contact w/2 units simultaneously. On rate: rate at which monomers are added. Rates inherent to protein themselves and cells can also manipulate rates.
