ANAT 262 Lecture Notes - Lecture 12: Intermediate Filament, Actomyosin Ring, Ftsz
30 Aug 2016
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Equilibrium: addition = loss of subunits to polymer. Lag phase can be bypassed by nucleating factors. Pulling on intermediate filaments pulls on entire cell. If appears to be continuous, not actually continuous. Epithelia: keratin if mutant weakened epidermis blister easily. Bacteria don"t have one cytoskeleton found in all, but have homologs. Like contractile ring of actin, but parallel to mt subunit tublin. At site of cell division, pinches off for division redistributed to middle division zone of daughter cells. An actin homolog binds membrane at division site, localizes ftsz for contraction. Similar formation of individual protofilaments, differ in how filaments come together. Differ in lateral contacts make sheets, not hollow tubes. Experiment: add ftsz + anchoring protein + nucleotides defined structures. Have 2 domains, each 2 subdomains 4 subdomains conserved, closes around atp. All assemble polymers as result of binding to nucleotide. Differ in interaction b/w individual protofilaments into full filaments.
