ANAT 322 Lecture Notes - Lecture 5: Periventricular Nucleus, Growth Hormone Secretagogue, Hypophyseal Portal System
14 Aug 2016
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Document Summary
Part i: regulation of gh secretion- gh-releasing hormone, somatostatin, and other factors. Hypothalamic: neuropeptides (ghrh, somatostatin, ghrein, npy, galanin, neurotransmitters (da, ne, epi, ach) Peripheral: (target feedback: thyroid hormones (t4, sex steroids (estrogens, androgens, glucocorticoids (cortisol, ghrelin leptin, fatty acids, aa, glucose, igf-1 (feedback) Social behaviours: sleep, exercise, nutrition, stress (including psychosocial) Expression and release of gh are mainly regulated by two antagonistic peptide hormones at the hypothalamic level: Not only at the level of secretion but also at the level of expression. Original isolation from human neuroendocrine pancreatic tumours that caused acromegaly. Expressed primarily in hypothalamus (arcuate nucleus, on top of me) Increases production and release of gh in somatotrophs. Crucial for final differentiation and proliferation of the somatotrope. Primary stimulator of pituitary gh synthesis and secretion. Ghrh effect on gh secretion in adult males. Two peptides produced from a 116 aa precursor. Expressed very abundantly in hypothalamic periventricular and arcuate nuclei.
