ANAT 322 Lecture Notes - Lecture 11: Gigantism, Octreotide, Insulin Resistance

• School: McGill University
• Department: Anatomy & Cell Biology
• Course: ANAT 322
• Professor: David Ragsdale

Document Summary

Pituitary are peptides; use circumventricular organs to cross blood-brain barrier (bbb open) Stress response: regulation of acth secretion from pituitary by crh from hypothalamus neurons. Most neurons producing crh are in paraventricular nucleus (pvn) of anterior hypothalamus. Pvn has magnocellular & parvocellular parts (more medial) Pvn is rostral axonal tracts through basal hypothalamus turn into median eminence from the side, terminate at capillaries. Adrenal gland: low levels of adrenal steroids (e. g cortisol) in blood parvocellular neurons in. Upper: control, normal staining for crh in external median eminence. Adrenal gland removed: all of median eminence full of crh. Pvn of hypothalamus, staining neuronal cell bodies for diff peptides made there. Normally only see vasopressin (made by magnocellular), don"t see crh staining. Magnocellular neurons cell biology diff from parvocellular; diff to stain parvocellular neuron cell bodies in hypothalamus for specific releasing hormones, because high turnover rate (precursor immediately transported along axons to me)