ANAT 322 Lecture Notes - Lecture 12: Proopiomelanocortin, Cortisone, Zona Glomerulosa
3 Sep 2016
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Document Summary
Primary integrator of neuroendocrine stress response is pvn of hypothalamus, express crf. Crf released at median eminence anterior pituitary, corticotropes produce pomc cleaved into acth, into general circulation adrenal cortex produce cortisol -ve feedback at pituitary. Sympathetic nervous system for immediate responses epinephrine by adrenal & norepinephrine e. g. reduce salivation dry mouth, increases heart rate, relaxes airway, relaxes urinary bladder, stimulate sweat glands, constricts blood vessels. Stress response needed for danger; then need to replenish system. Gcs transiently enhance immune function, but depress immune function long-term. Chronic stress exposure affect reproduction & growth (psychological dwarfism, affect gh) Redirect oxygen & nutrients to muscle, heart, brain. Limbic system (amygdala, ventral subiculum, prefrontal cortex, lateral septal complex) indirect, go through bnst pvn of hypothalamus. Direct (arc, dmh, perifornical lha) & indirect (vmh, lha) within hypothalamus. Sauvagine in frog, urotensin in carp; homologous to crf. Remove adrenal (remove ve feedback from gcs) upregulation of crf.
