ANAT 365 Lecture Notes - Lecture 20: Synaptic Vesicle, Secretion, Neuropeptide Y

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Release from 2 diff organelles, but both ca2+ release steps. Both synaptic vesicles & dcv from same compartment: presynaptic compartment at end of axon. * released from active zone after post-synaptic density. * responsible for all fast neurotransmission (receptors are ligand-gated ion channels, small synaptic cleft) (gpcr, tyrosine kinase) slow neurotransmission. Classical transmitters: synthesized by enzymes (don"t go through er), need specific vesicular transporter to get packaged into synaptic vesicle. * no gene encoding ach, serotonin, dopamine, etc. * but genes encoding enzymes for synthesis of the nt. But is gene encoding opioids, neuropeptide y, etc. Synaptic vesicles formed from endocytosis or through endosomes. * vast majority of synaptic vesicles are reused, need lots quickly. Only endocrine cells & neurons only have regulated dcv pathway. Neuropeptide may not be able to aggregate by self, facilitated aggregation. Aggregates retained (selective retention), other stuff bud off. Overexpress in diff cell that doesn"t normally make regulated secretory granules: appears dcv in tgn.

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