ANAT 381 Lecture Notes - Lecture 14: Intermediate Mesoderm, Lateral Plate Mesoderm, Programmed Cell Death

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Examples of signaling molecules secreted by organizers. Cytoplasmic polarity (asymmetric localization of maternal transcripts) Asymmetric protein gradients due to translation of asymmetrically localized mrnas. Restricted zones of expression of zygotic mrnas (gap genes). Stripes of expression of pair-rule genes . Repeated stripes, setting up an initial patterning. Stripes of pair-rule genes turn on segment polarity genes (components of wnt and. Patterns of eve and ftz follow the imaginary boundary of the parasegment (are in. In between eve or ftz stripes, the cell turns on wg (related to wnt signaling). In the cell posterior to wg, the transcription factor en is turned on turned on at alternating parasegments). the anterior boundary of each stripe of eve and ftz. Engrailed (en) comes on in cells expressing eve and ftz but only 1 cell/stripe; 14 rows = posterior cell of segment; anterior cell of parasegment. Wg cell forms between stripes of eve and ftz.

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