ANAT 381 Lecture Notes - Lecture 19: Feedback, Prc2, Lysine

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There are lots of features that are in common with imprinting. Example of where the genes on one chromosome are expressed and the others on. Gene dosage compensation in species with dimorphic sex chromosomes. X chromosome inactivation falls in the category of gene dosage compensation, which affects all species that have dimorphic sex chromosomes (the male and the female have different sex chromosome complements). There are a variety of different strategies throughout evolution that organisms have used to deal with this problem". Dimorphic sex chromosomes lead to dosage imbalances between homogametic and heterogametic sexes (imbalances in gene expression). In mammals where females have two x chromosomes will express twice as much of the genes on the x chromosome. Flies: the males do something special on their x chromosome for the genes to be doubly. In mammals: in females, inactivation of on x functionally, have one x chromosome, Properties of the inactive x chromosome (xi)

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