ANAT 416 Lecture Notes - Lecture 3: Stim, Macrophage, Diabetic Foot

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Jan 17 // lec 3 // skin regeneration 1 // a bateman. Protective layer to prevet dehydration, is a barrier. Granular layer = cells secrete lipids from keratohyalin bodies, to provide waterproofing, nucleus slowly degrades as cell moves up. Basal layer = mitotically active cells, move upwards to die o o. Reticular layer has more structured matrix, hair roots and blood vessels here. Regen in healthy situation, only epidermis is continually renewed o. Hair follicle has a sebaceous gland and a bulge just underneath the gland. Dermal papilla is dark spot at bottom of hair root, special mesenchymal fibroblasts. If you block dp = halt hair follicle cycling, fail to form in dev o. Catagen: degradation of lower 2/3 of follicle, up to the bulge region o. Placode: increased density of epithelial cells, forms demal condensate/dc of mesenchyma cells beneath it. Due to wnt signalling, fibroblast growth factors/fgf, bmp.

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