ANAT 416 Lecture Notes - Lecture 9: Brain Tumor, Epigenetics, Growth Cone
Feb 7 // lec 9 // dev and cancer 1 // f charron. Focus on shh: what is it, roles during dev, esp shh as a mitogen for cerebellum dev. How to use dev to understand diseases esp cancer. Tumor biopsy, then deep sequencing to find what mutations are in the tumor cells and not in normal cells. Ex. of how devbio help us design cancer therapy drugs. Historically known, even to ancient egyptians, but very rare bc ppl didn"t live long enough. When lifespan incr due to control of infectious disease, cancer become more common. 1/4 men, 1/5 women will die of it. Cellular disorder, usually appears as tumor when diagnosed, but tumor is really the end point. Act like nucleotides to halt replication by its incorporation. Often act on any cell that"s high turnover, so gut/blood cells are side effects. Most cases, the metastasis is what kills ppl, not primary tumor.