ANAT 416 Lecture Notes - Lecture 10: Cyclopamine, Biopsy, Prodrug

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Feb 9 // lec 10 // dev and cancer 2 // f charron. Smo (and thus signalling of shh) blocked by cyclopamine, sant-1, hhntag. Many cancers are linked to aberrant shh signalling. Keep making more bcc tumors, so continued biopsy is limited. You eventually run out of skin to remove! 25% all medulloblastomas are linked to shh abnormality --> gcp fails to exit cell cycle, remains proliferating at egl layer of cerebellum. Is a pediatric cancer bc common in kids. Most common solid cancer in kids, probably bc gcp ae high-prolif during childhood. Treatment is v aggressive, can cause neuro problems. Esp. bc kid = more % cells are still proliffing for growth, so radio/chemo targetting is less specific to cancer cells. Ptc+/- mouse model = only 50% (not 100%) dev mb and die from motor coord defects. 2-hit model for progression to mb: loh/loss of heterozygosity. In mice with mb, see pre-neoplastic region on surface of cerebellum.

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