ANAT 416 Lecture Notes - Lecture 11: Myc, Progenitor Cell, Cell Potency
Feb 14 // lec 11 // stem cells 1 // l mccaffrey. It is possible for a population to maintain self-renewal, but this self-renewal is not necessarily maintained at the individual stem cell level. quiescent (reserve stem cells) or proliferating (active stem cell) Reserve sc may only divide a few times in the organism"s life. Skin and gut epithelial stem cells proliferate often, high turnover rate. These regions also have reserve stem cells that become active in cases of severe tissue damage. Sc retain plasticity: can change their gene expression to adopt different cell fates. Differentiated cells have a more stable gene expression profile. Differentiated state: stable normally, but can change therapeutically or thru disease -- cancer. Cancer = revert to stem-like state to incr plasticity to drive heterogeneity of tumor tissue. It is important to note that modern stem cell biology really challenges these three ideas. Transit amplifying cells rapidly dividing progeny, for cell expansion.