ANAT 416 Lecture 14: Neural Connectivity 2
3 Jun 2020
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Feb 23 // lec 14 // neural connectivity 2 // h takahashi. Dendritic spine numbers increase in childhood due to synapse formation, begin to decrease during synapse elimination in adolescence, and the rest are maintained throughout adulthood. Spines too few/small bc too much pruning = schizo, alzh. Spines too many/not trimmed = asd/autism spectrum disorders. Other symptoms: motor issues, sensory overload, self-injurious behaviour, safety issues. Then subsequent assessment of behaviour by 3-chamber sociability test (mouse can move freely between three chambers, where a stranger is kept in one chamber) = mutant mice show social interaction deficit show fewer social interactions than wt who were attracted to interact w stranger. R451c mutation = impairs nlgn3 synthesis, enhances inhibitory synaptic transmission = leading to excitation/inhibition imbalance. Optogenetically-induced excitation/inhibition imbalance, especially in prefrontal cortex, leads to a social interaction deficit. The modulation of prefrontal cortex e/i imbalance can rescue social behaviour in autism mouse model (cntnap2-deficient gaba signal deficits)
