ANAT 416 Lecture Notes - Lecture 17: Cancer Stem Cell, Ovarian Cancer, Breast Cancer
3 Jun 2020
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Mar 16 // lec 17 // cancer stem cells // l mccaffrey. Change in growth not just hyperplasia but de-differentiation, more progenitor cells (yellow/green) Not faster, but less stopping bc defective cell cycle checkpoints (p53, prb) No, u need to be able to provide nutrients to all those new cells. [discussion about why cancer is so challenging to deal with] How many markers need to be present to be classified as x cancer type. Tumours so heterogenous, as long as around 10% or any sort presence makes it count. Er-alpha found in 10% cells, then docs will treat it with tamoxifen (bind er) even though that obviously only works for those 10% of cells. All cells in dom population are genetically/phenotypically similar in tumorigenic potential. Collagen1 can induce a cell to become metastatic. All together: cancers in which heterogeneity is determined by csc diff, clonal evo and enviro. Irl, this probably happening in most real tumors.
