ANAT 416 Lecture Notes - Lecture 18: Cancer Stem Cell, Cd38, Cd24

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Mar 21 // lec 18 // cancer stem cells // l mccaffrey. Last lec, he only got like halfway through his slides, so we"re starting from there. Csc: a+b+ = csc, only this subset can form tumor and maintain it indefinitely. A+b- = unable to form tumor or maintain one. Clonal evol: lose heterogeneity from previous tumor, can"t recapitulate it. Csc: put in csc, tumor recapitulates heterogeneity of original tumor. In a real complex patient, you probably get both csc and clonal evol. Experiments usually designed based around either clonal evol model or csc model, none mix them. First proof of csc was aml/acute myeloid leukemia. First proof of csc in solid tumor was breca. 2 populations of cells identified with surface markers. Cd34+/cd38- = tumor initiating capacity, minor population,

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