ANAT 565 Lecture Notes - Lecture 10: Phospholipid, Sterol Regulatory Element-Binding Protein, Cyclic Adenosine Monophosphate
3 Sep 2016
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Document Summary
Cholesterol ester: fatty acid linked to hydroxyl of cholesterol, oh gives little polarity. Aren"t soluble in water, transported/stored using special means. Diglycerols can be made in many diff ways, diff locations. Cholesterol esters synthesized by acat, also in er membrane. Cholesterol has oh for polarity, but not water-soluble. Cholesterol ester: storage form, cholesterol-fatty acid, completely hydrophobic & insoluble in water. Lipid droplets in cytoplasm or lipoprotein into er lumen & secreted. Lipoproteins only produced in er of hepatocytes & enterocytes in intestine, except hdl. Secreted into bloodstream, can be endocytosed by other cells. Lipoprotein only way to move cholesterol b/w cells, major way to move fa b/w cells. Lipid droplets can be produced by any cell type, produced in cytoplasm and can"t leave cytoplasm of that cell. Acat1 in all types, acat2 in cells that secrete lipoprotein particles. Doesn"t function w/low cholesterol, produces cholesterol ester when high cholesterol. But all cell types can receive lipoprotein particles.
