ANSC 234 Lecture Notes - Lecture 2: Signal Transduction, Tyrosine, Grb2
30 Oct 2017
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Cells/organs/whole animals respond to signals that are out there. Receptors can be found anywhere in the cell. Trh: hormone that is released by the hypothalamus. Adrenalin: its receptors are in the liver, body fat, and muscle cells. When it binds it releases glucose from glucose storage. When it binds in the liver it inhibits glycolysis. Amplification: activation of one enzyme can amplify the enzymes activated at level 3. Desensitization: signal goes to receptor and gives a response and some of it goes back and inhibits. Like s(cid:373)ell, ho(cid:449) after a (cid:449)hile you do(cid:374)"t s(cid:373)ell the s(cid:373)ell a(cid:374)y(cid:373)ore. Integration: the overall response depends on the receptor/ligand interactions. Ligand receptor interaction can lead to a response or lead to a cascade of signal transduction leading to a response. Gpcr: class of proteins highly targeted by drugs. We do(cid:374)"t k(cid:374)o(cid:449) ho(cid:449) (cid:373)a(cid:374)y gpcr there are. Has two parts: receptor that is 7 pass and group of protein complexes and has three parts.
