Class Notes (837,687)
Canada (510,396)
Biology (Sci) (2,472)
BIOL 112 (307)

Enzymes and Glycolysis

3 Pages
Unlock Document

Biology (Sci)
BIOL 112
Frieder Schoeck

← Lecture 10 ← Enzymes and Glycolysis ← Friday February 8 2013 ← ← Catalyst: any substance that speeds up a chemical reaction without itself being used up • Only reactions with overall –ΔG can be catalyzed • Biological systems can’t initiate reactions by adding heat therefore enzymes are used to lower the activation energy ← ← Enzymes • bind to the active site on specific substrates where they catalyze • catalyze reactions by using 1+ of: o Orienting substrates o Inducing strain in the substrates o Adding charges to substrates • Cofactors: metal ions/small organic molecules that are temp or permanently bound to the enzyme – required for some enzymes • Enzymes (E’s) get saturated when all binding sites are occupied • Metabolic Pathways o Feedback inhibition end-product regulates the whole pathway o Each reaction in the path is catalyzed by a specific enzyme • Enzyme Regulation o E activity can be inhibited by natural and artificial binders, some are irreversible b/c they destroy the enzyme o Competitive inhibitor: binds reversibly to an E’s active site o Noncompetitive inhibitor/negative allosteric regulator: changes the shape of the E by binding reversibly to somewhere other than the active site, ends up changing the active site so it can’t bind with the substrate o Allosteric regulators: can stabilize the active form (+ allosteric regulator) or stabilize the inactive form (- A. R) of the E  Much more efficient than competitive inhibition  Cooperative allosteric transition: occurs with 2+ subunits  When 1 binding site is occupied, it changes the others so that they bind other substrates more readily  E activation or inhibition occurs very quickly  First step in a metabolic pathway almost always a multi-subunit E negatively regulated by cooperative allostery Glycolysis and Redox Reactions • Glycolysis is followed by 2 metabolic processes o 1. Cellular
More Less

Related notes for BIOL 112

Log In


Join OneClass

Access over 10 million pages of study
documents for 1.3 million courses.

Sign up

Join to view


By registering, I agree to the Terms and Privacy Policies
Already have an account?
Just a few more details

So we can recommend you notes for your school.

Reset Password

Please enter below the email address you registered with and we will send you a link to reset your password.

Add your courses

Get notes from the top students in your class.