BIOL 112 Lecture Notes - Lecture 4: Pyrophosphate, Energy Carrier, Nitrogenous Base

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27 Apr 2017
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BIOL 112 Full Course Notes
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20 amino acids are linked together with a peptide linkage (it is a covalent bond) to form a polypeptide chain. There are some polar, non-polar, charged, or hydrophobic amino acids. To know what class an amino acid belongs to: look at the side chain. The sequence of amino acids determines how protein can fold. First thing that happens: secondary structure forms (easiest type of folding). Weather you get and alpha-helix or a beta-pleated sheet depends on the primary sequence of amino acids. a-helix sheets and b-pleated sheets form with hydrogen bonds within the back bone. How a-helix and b-pleated sheets are arranged is random. In the se(cid:272)ondar(cid:455) stru(cid:272)ture, side (cid:272)hains don t do an(cid:455)thing. It is not folded yet, we need the tertiary structure. There can be many type of bonds: hydrogen bonds, hydrophobic bonds, disulfide bonds (only covalent bon in tertiary structures), ionic bonds. All of these bonds help shape the final form of the protein.

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