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Lecture 6

DENT LECTURE 6 Breaking the Genetic Code.pdf

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McGill University
Biology (Sci)
BIOL 112
Lucy- Ann Joseph

DENT LECTURE 6 Breaking the Genetic CodeRecallthe key to DNAThe sequence of nucleotides is not constrained by the structure DNA can accommodate any sequence An arbitrary sequence can encode informationThe two strands of DNA encode the same information in complementary form suggesting a method of replication Mendelian Inheritance AlkaptonureaNeither parent affected 311Pee blackAlmost all affected parents give rise to unaffected progeny therefore not dominantHowever in one rare case where affected father had affected children50 children were affectedtest crossGarrodshows that it is a recessive hereditary traitHe deduces that it results from the absence of a specific enzymeThus geneenzymeBeadle and TatumOne geneone enzymeOne geneone proteinDNA in nucleus protein made in the cytoplasmRNA transfers the genetic information from thenucleus to the cytoplasm where p
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