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Lecture

hnRNA defs.docx

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Department
Biology (Sci)
Course
BIOL 200
Professor
Francois Fagotto
Semester
Fall

Description
hnRNA: An assortment of RNA molecules assembled around newly transcribed RNA (pre- messenger RNA, or pre-mRNA) in the cell nucleus. The hnRNA associates with proteins to form heterogeneous nuclear ribonucleoprotein (hnRNP). After release from the chromosome and processing of the pre-mRNA by the spliceosome (see intron), the mature messenger RNA remains associated with various proteins, forming a messenger ribonucleoprotein (mRNP), which is then exported from the nucleus hnRNP: Heterogeneous nuclear ribonucleoproteins (hnRNPs) are complexes of RNA and protein present in the cell nucleus during gene transcription and subsequent post- transcriptional modification of the newly synthesized RNA (pre-mRNA). The presence of the proteins bound to a pre-mRNA molecule serves as a signal that the pre-mRNA is not yet fully processed and ready for export to the cytoplasm. After splicing has occurred, the proteins remain bound to spliced introns and target them for degradation. snRNA: Short RNAs, and forms complexes with proteins in snRNPs. snRNAs are involved in RNA processing such as splicing and polyadenylation. snRNP: Small nuclear ribonucleoprotein (RNA plus protein) particle. Component of the spliceosome, the intron-removing apparatus in eukaryotic nuclei . mRNA: In prokaryotes, mRNA is derived from a large primary transcript from a DNA sequence. The mRNAs of prokaryotes are usually very short lived (from seconds to more than an hour) and
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