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Lecture 1 - Sept 7.pdf

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McGill University
Biology (Sci)
BIOL 200
Richard Roy

BIOL200 Lecture 1 - Sept. 7 Introduction: • Central Dogma of Biology • DNA → (Transcription) → RNA → (Translation) → Protein • Nucleotides are the building blocks of nucleic acids • RNA = ribonucleic acid (<100 to 1000s of nucleotides long) • DNA = deoxyribonucleic acid (as long as several hundreds of millions of nucleotides long) Nucleotide Monomers: Phosphate group provides acidic character. Under intracellular conditions, the phosphate group is • negatively charged • Phosphate group linked by a phosphoester bond to a pentose (five carbon) sugar molecule • Difference between ‘Ribose’ and ‘2-Deoxyribose’ lies in one hydroxide group (OH vs. H) • Pentose is linked to a nitrogen- and carbon- containing ring structure referred to as a base • Purines are seen with a fused ring while pyrimidines do not have a fused ring • RNA has Uracil (U) as a pyrimidines instead of Thymine (T) which is used in DNA Nucleosides are sugar and base without phosphate group • • Amino acids are the building blocks of polypeptides • Proteins are
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