Class Notes (786,433)
Canada (482,181)
Biology (Sci) (2,293)
BIOL 200 (486)

Nucleic Acid Structure

2 Pages
Unlock Document

McGill University
Biology (Sci)
BIOL 200
Monique Zetka

PHGY-209 Lecture 3 September 9, 2013 DNAand RNAare linear polymers of monomers called nucleotides -pentose phosphate backbone deoxyribose (DNA), ribose (RNA) hydroxyl in 3' end engages in polymer nucleic acid polymers are directional: free 5' phosphate group free 3' hydroyxl group -phosphodiester bonds link the groups (one from each base) together READ in 5' to 3' direction Watson-Crick base pairing (A-T, C-G) -in lab(in vitro), artificial DNAcan be produced with G-T and C-T base pairs enzymes try to correct anomalies in base pairing ssRNAcan have double helical regions w/ G-U base pairing slide 8 yellow: H-bonds, van-der Waals interactions, hydrophobic interactions phosphate backbone: -ve charged blue and red: bases interaction w/ each other w/ diff. # of H-bonds CG: 3H-bonds, more stableAT: 2 H-bonds you can move around DNAalong longitudal axis b/c no H-bonds formed (no spacing) beta DNA: in humans, “classical form” RNA can interact w/ DNA: A DNA = less helical turns than in B DNA proteins can regulate DNAtranscription through morphology (binding to DNA) DNA binding proteins can bend DNA -necessary for DNA to be packed in chromatin TATAbox-binding protein binds to TATA box -highly conserved -in euk: transcription for those genes require TBP binding to their promoters
More Less

Related notes for BIOL 200

Log In


Don't have an account?

Join OneClass

Access over 10 million pages of study
documents for 1.3 million courses.

Sign up

Join to view


By registering, I agree to the Terms and Privacy Policies
Already have an account?
Just a few more details

So we can recommend you notes for your school.

Reset Password

Please enter below the email address you registered with and we will send you a link to reset your password.

Add your courses

Get notes from the top students in your class.