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Lecture

Nucleic Acid Structure

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School
McGill University
Department
Biology (Sci)
Course
BIOL 200
Professor
Monique Zetka
Semester
Fall

Description
PHGY-209 Lecture 3 September 9, 2013 DNAand RNAare linear polymers of monomers called nucleotides -pentose phosphate backbone deoxyribose (DNA), ribose (RNA) hydroxyl in 3' end engages in polymer nucleic acid polymers are directional: free 5' phosphate group free 3' hydroyxl group -phosphodiester bonds link the groups (one from each base) together READ in 5' to 3' direction Watson-Crick base pairing (A-T, C-G) -in lab(in vitro), artificial DNAcan be produced with G-T and C-T base pairs enzymes try to correct anomalies in base pairing ssRNAcan have double helical regions w/ G-U base pairing slide 8 yellow: H-bonds, van-der Waals interactions, hydrophobic interactions phosphate backbone: -ve charged blue and red: bases interaction w/ each other w/ diff. # of H-bonds CG: 3H-bonds, more stableAT: 2 H-bonds you can move around DNAalong longitudal axis b/c no H-bonds formed (no spacing) beta DNA: in humans, “classical form” RNA can interact w/ DNA: A DNA = less helical turns than in B DNA proteins can regulate DNAtranscription through morphology (binding to DNA) DNA binding proteins can bend DNA -necessary for DNA to be packed in chromatin TATAbox-binding protein binds to TATA box -highly conserved -in euk: transcription for those genes require TBP binding to their promoters
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