BIOL 201 Lecture Notes - Lecture 3: Glyceraldehyde 3-Phosphate, Isoniazid, Wallerian Degeneration
25 Feb 2013
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Document Summary
Transition state theory: how the reactants reach the energy state of the intermediate. Energy states of a molecule fluctuate, following a distribution. Coupling uses enzymes to physically bring together the two reactions. Atp, with its highly negative charge, is capable of changing the structure of a protein, activating it or. Change of charge allows for a redox reaction, an oxidization reaction of the energy source, forcing a reduction coupled to the oxidation, which carries energy. In the case of metabolic processes, glucose donates electrons to nad+, making nad+ into nadh. E. g. isoniazid actively blocks nadh pathway, preventing tuberculosis bacterial cell wall synthesis. When breaks appear, instead of being repaired, the axon degenerates back to the cell body, instead of regrowing. In wlds mutated mice, nad+ is overproduced, which delays wallerian degeneration. Fad and fadh2: lesser version of nad+, carry less energy, fills up the last bit of collected energy.
