Transition State Theory: how the reactants reach the energy state of the intermediate. Energy states of
a molecule fluctuate, following a distribution.
Coupling of reactions make unfavourable reactions favourable. Coupling uses enzymes to physically
bring together the two reactions.
ATP, with its highly negative charge, is capable of changing the structure of a protein, “activating” it or
“deactivating” it through phosphorylation. Change of charge allows for a redox reaction, an oxidization
reaction of the energy source, forcing a reduction coupled to the oxidation, which carries energy.
In the case of metabolic processes, glucose donates electrons to NAD+, making NAD