BIOL 201 Lecture Notes - Lecture 8: Malonyl-Coa, Ketone Bodies, Gluconeogenesis

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Netproduction of 4 nadh, 2 fadh2, 2 atp through the process. Added with the production of glycolysis and pyruvate oxidation, the total then would result in 8 nadh, 2 fadh2 and 4 atp. 2 nadh are produced through the pyruvate oxidation process. Oxaloacetate conc. is very low in the mitochondria. The final step in reforming oxaloacetate is possible due to the le chatelier"s principle, since as soon as oxaloacetate is formed it is consumed, the equilibrium will always be pushed towards the formation of oxaloacetate. Many of the enzymes are associated with each other in order to speed up the reaction and make it more efficient. However, the succinate dehydrogenase is a part of the inner membrane. Isocitrate dehydrogenase is negatively regulated by atp and nadh, but is enhanced by adp. The ketoglutarate dehydrogenase complex is negatively regulated by the same, and also succinyl coa. The intermediate products of the kreb"s cycle serve as the precursors for other molecules.

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