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Lecture 11

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McGill University
Biology (Sci)
BIOL 202
Daniel Schoen

In the conferences, TA's bring their own problems in addition to the problem sets, to give insight into the kind of problems we will be faced with. Should be done problem set 3 REALLY NEED TO FIND A COPY OF THE 10TH EDITION Quantitative traits, (polygenic or continuously varying traits) trying to understand the underlying genetic basis of these kind of traits....difficult cuz under influence of multiple genes, hard to tease apart, also, there is environmental noise interrupting this. In order for a trait to respond, there has to be some contribution of the gene (heritability) to the offspring? Only when you have heritable variation that you can see some kind of response to selection. Important to know if theres underlying heritable basis. If a disease is genetic, maybe we can target that gene for therapeutic purposes. (important both in agriculture and in medicine) If you have a population wt a lot of variation (ex: bristles on drosophila) you can select upwards or downwards from 36 bristles relatively easily, theres not much heritable variation at some point. The dotted line, the population reverted back a little bit, then jumped back up, because 1) could be mutations that have increased variance for bristle number 2) could be recombinations, recombining with other genes (hadnt run out of variation for bristle number...recombination can mix up that variation) have genes all over the genome that affect the gene of interest. (deleterious=???) Heritability in the broad sense is H2=Vg/Vx 2 ways to get it. We cant clone humans, but humans come close to cloning themselves. The heritability of political conservatism is slightlyl heritable (?).. In twin studies, having twins isnt sufficient . You need twins that have been separated at birth and raised in different environments to study. The 3 height graphs show something. (recall heritability =Vg/Vx....a correlation value could be equal to this, in the textbook this is shown) you can only get broad sense heritability of twins when you have separated them at birth. You get phenotypic correlation in environments if they are not separated, otherwise, you can't tell if environment or gene type is responsible for this. Also adoption isnt perfectly good, because twins often get adopted into similar environments Take personaility attributes and some physical heritability values wt a grain of salt Narrow sense heritability h2= Va/Vx (additive component of genetic variation/all components of genetic variation) the narrow one tells us more about what we can select additive gene action, when you have the heterozygote exactly in between the dominant and recessive genotypes in much each individaul gene changes the genotype LOOKAT TEXTBOOK know that genes can combine and thi
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