BIOL 202 Lecture Notes - Lecture 8: Osteogenesis Imperfecta, Collagen, Wild Type
25 Feb 2013
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Document Summary
Survivability expectations requires compensation in the expected values. This change results in a decrease in the degree of freedom, since information was consumed in order to generate data. Sequence multiple times, overlap to produce full map of the chromosome. Line up the phenotypic and the recombinant map to sandwich in the desired trait is. Narrows down to a region of candidate genes. Homogentisic acid builds up in tissues and in urine, leading to black urine when exposed to oxygen. This solves the problem of a lack of precursor for a functioning gene. Solved by providing the precursor for the enzyme. Cystic fibrosis: viscous secretion caused by mutation in the cftr gene, leading to a problem with chloride and sodium transport. A haplosufficiency is one in which a half dose of a gene (1 allele) is enough to provide for a wild type phenotype. If they are not sufficient, then a complete dominance emerges.
