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Lecture 13

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Biology (Sci)
BIOL 202
Mario Chevrette

Lecture 13 Population Genetics II Hardy-Weinberg Theory: Cystic fibrosis is a recessive disease. 1 in 25 people are carrier. Retinitis pigmentosa: retina damage and tunnel vision, etc. 5/10000 may have it, but In Tristan de Cuhna, 100 more prevalent. What happens to allele and genotype frequencies in the absence of evolutionary forces? Random mating in this case would generate the same allele frequencies. At a diallelic locus, in the next 2 2 generation would be p , 2pq and q . This frequencies continue on unchanged until something changes. When alleles are very rare, the rate of heterozygotes is much higher than homozygous rate. At population levels, Mendelian genetics is maintained. Non-Random Mating: Inbreeding Self-fertilization: inbreeding coefficient of 1. Heterozygotes are halved every gener
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