BIOL 202 Lecture Notes - Lecture 13: Inbreeding Depression, Mutation, Retinitis Pigmentosa
25 Feb 2013
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Retinitis pigmentosa: retina damage and tunnel vision, etc. 5/10000 may have it, but in tristan de. Random mating in this case would generate the same allele frequencies. At a diallelic locus, in the next generation would be p2, 2pq and q2. This frequencies continue on unchanged until something changes. When alleles are very rare, the rate of heterozygotes is much higher than homozygous rate. Population shifting to p and q without any heterozygotes. Inbreeding coefficient: let f = inbreeding coefficient between 0 and 1. Inbreeding depression in humans is based upon deleterious mutations that harbour no disease, but reduce overall survivability. Mutation is very slow, one in a million every generation. By itself, would take many generations to result in visible genotypic changes in a population. Migration introduces new gene forms from another source. The amish has a high rate of ellis-van creveld syndrome, which affects the bones and the heart.
