BIOL 300 Lecture Notes - Lecture 18: Inosine, Amine, Apobec1

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In addition to splicing, there are some more exotic types of rna modifications, one of these is rna editing, which involves chemical changes individual nucleotides to the primary transcript (pre-mrna) It could also affect stability of the mrna, as well as export of the mrna into the cytoplasm, and even the localization of the mrna. If the modification occurs at a splicing related area, it can result in alternative splicing of the protein: editing of regulatory. Rnas like mirnas can have functions as well. Shock: very commonly, these mismatches between cdna and genomic dna could simply be errors in the sequencing machine. No one knows the purpose of this editing: apart from this, there are not many examples of rna editing which have been researched and understood in detail. The first example of rna editing is in the liver and intestines in the apolipoprotein b gene (apob) involved in cholesterol uptake.

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