BIOL 300 Lecture Notes - Lecture 11: Transcription Factor Ii H, Transcription Preinitiation Complex, Heptad Repeat
5 Mar 2018
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Lecture 11: transcription elongation: elongation is difficult to study because by definition, the polymerase is moving along the. Dna: it"s not at a fixed point: 1. Factors which act on naked dna: identified as factors that can overcome sequence-dependent or drug-induced arrest of. Pol ii (ex: tfiis and ptefb: identified as factors that can boost the rate of mrna synthesis (ex: tfiif, elongins, Factors which regulate the rate of elongation through chromatin (ex: fact & elongator) Tfiis: ubiquitous (found in all eukaryotes from yeast to man. Bacterial rna polymerase and greb (right: the position of the conserved acidic residue in tfiis and greb are indicated by the small green circles. The nascent transcript is shown in red and the dna template is blue. The steps in phosphorylation of target proteins by a cyclin cdk complex. Negative regulators of elongation: dsif: drb sensitivity inducing factor, heterodimer, expressed ubiquitously in eukaryotes, nelf: negative elongation factor, multiprotein complex.
