BIOL 300 Lecture Notes - Lecture 21: Ferritin, Royal Aircraft Factory F.E.2, Mutation

• School: McGill University
• Department: Biology
• Course: BIOL 300
• Professor: Frieder Schoeck

Document Summary

Nonsense-mediated decay (nmd: the degradation of rna that carries pre-mature stop codons, such pre-mature stop codon can only be recognized in the cytoplasm by the ribosome the degradation much occur in the cytoplasm. Upf1 can bind both the release factor erf3 and upf2. What happens after: the ribosome falls off the premature termination codon so the ribosome can be reused, the upfs then can degrade the rna, they deadenylate the rna. How do we get such pre-mature termination codon: 1. Normally the ribosome has no problem reading through these secondary structures due to its unwinding capacities. Speed of regulation: one interesting thing to note is that regulation happens faster and faster: transcriptional regulation is slow, rna regulation is faster, translational regulation is even faster and post- translational regulation is super fast. 2: in transcriptional regulation, you have to recruit transcription factors to the nucleus, you have to make rna in order to make proteins.