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Lecture 8

Study Questions for Lecture 8 Study question answers for lecture 8.

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Biology (Sci)
BIOL 303
Dragana Miskovic

1Define proximaldistal anteriorposterior and dorsalventral limb axisProximaldistal three segments stylopod proximal zeugopod and autopod distal develop in sequence Cartilage is replaced by the sequence above in orderAnteriorposterior small fingers pinky posterior and thumb anteriorDorsalventral Palm is ventral and knuckles nails are dorsal2Is the following statement true or false Wnt proteins stimulate the degradation of Fgf10 in the lateral plate mesoderm thereby initiating limb bud formationExplain your reasoningThis is false because Fgf10 that is in the lateral plate mesoderm signals which induces the formation of limbs3Describe the roles of Fgf10 Fgf8 Wnt2b Wnt8c and Wnt3a in the initiation of the chicken limb bud formation How the above molecules interact with each other to signal the formation of the limb budFgf10 is secreted by lateral plate mesoderm it is an inductive signal for limb formationFgf8 expressed in ectoderm at limb budWnt2bis restricted to the chick forelimb regionWnt8c is restricted to the chicks hindlimb areaWnt3a expressed in ectoderm at limb budsThe expression of the lateral plate mesoderm Fgf10 regulates Fgf8 and Wnt3a4Describe the roles of FGFs Tbx5 and Tbx4 during limb bud formation in the chick jOutline the experiments which demonstrated the roles of the above proteinsThe roles of FGFs impregnated beads the gain of function in the limb Tbx5 specifies limb bud to be expressed as forelimbs wings and Tbx4 specifies limb bud to be expressed as hindlimbs legs If he site between the limbs contain FGF it induces chimericlimb part forelimb and part hindlimb 5What is AER What is PZ How is the interaction between AER and PZ governing the limb growthAER is the apical ectodermal region which is the overlying ectoderm that is formed by FGF10 secreted by mesenchyme cells entering the limb fields AER runs along the distal margin of limb bud which function as major signaling centrePZ is the progress zone is the proliferating distal bud mesenchyme just under ERAER interacts with the limb bud mesenchyme the progress zone PZ which is directly below it I keeps it in a state of mitotic proliferation so the limb bud can grow and prevent those cells from forming cartilage before the right time
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