BIOC 212 Lecture Notes - Lecture 26: Arginine, Small Molecule, Lysine

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Cell Junctions & Cell Adhesion VI
!
Cell Adhesion
Short interactions between cells (transient)
Example from early development
o Neural tube
o Some cells on top of neural tube start migrating out of the tube & proliferate
(green)
Express certain cell adhesion molecules that guide their migration
Migrate down neural tube along matrix proteins
Eventually find their targets and bundle up
Differentiate further into peripheral ganglia for example
o Require transient cell-cell adhesions using adhesions molecules (CAMs)
Cell adhesion mechanisms when cells migrate over other cells or when they
assemble into tissues / repair mechanisms
Precursor cells (ECM, other cells)
Selective adhesions
Progeny of the founder cell are retained in the epithelium by the basal lamina &
cell-cell adhesion mechanisms, including formation of intercellular junctions
o Mechanisms require cell motility, cell adhesion, chemotaxis &
chemorepulsion, pathway guidance, etc.
Changing Pattern of CAMs (Cadherins)
Neural tube constricts and is pinched off
o Expression of different isoforms of cadherins
E-Cadherin in ectoderm
N-cadherin in neural tube
Cadherin 6B at the junction
Cells start growing and start expressing cadherin 7
o Organize and further differentiate
Fine tuned expression pattern of different cadherins
Changing patterns of CAMs during construction of the nervous system
Cross-section of early chick embryos as neural tube detaches from ectoderm and
as the neural crest cells detach from the neural tube
Immunofluorescence on top
As pattern of gene expression change, different groups of cells aggregate from one
another according to the cadherins they express
Cell Dissociation Experiments
Early in development (embryo) is very squishy and has little structural stability
between cells
Embryonic tissue: easy dissociation of cells, using:
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