BIOC 212 Lecture Notes - Lecture 69: Mdm2, Cln3, P53
18 Jul 2018
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Document Summary
G1-cyclins: there are dna-binding proteins that cover the dna, g1-cyclins (in yeast called cln3) that can bind to these dna-binding proteins. If cell has a certain size, all of these cyclins are bound such that do not have any free. G1-cyclins that could drive cells into cell division: cell keeps growing, increasing in size; more proteins, more g1 cyclins, up to a point where all dna-binding proteins are covered with g1 cyclins. If cell keeps growing, produce more g1-cyclin which is in excess of these red proteins: can now initiate s phase, amount of protein in the cell at some point eventually tells the cell that have enough to divide. Checkpoints: dna-damage checkpoint, checkpoint that senses if the dna is damaged (occurs commonly) Cell-cycle arrest: when cell cycle arrest occurs, dna repair enzymes will fix the damage, as soon as it is repaired, the pathway to be reversed.
