BIOC 212 Lecture Notes - Lecture 19: Repressor, Sacrum, Ultrabithorax
17 Aug 2018
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Document Summary
Signal that is coming from the notochord to the floor plate where it induces more of shh to be produced. Shh will diffuse from ventral to dorsal. Morphogen cells will adapt their fate according to concentration and exposure time to shh. Shh is vertebrate version and there are three analogous invertebrate: sonic, indian and desert hedgehog. Cyclopamine is a natural inhibitor of smo found in the plant veratrum calfornicum. In high altitude in the west: when the cattle eat this plant, they are born as cyclops (cyclopia holoprosencephaly, brain only has a single hemisphere. Proboscis in the forehead, the cells that will form the nose: migrate between the eyes, but when there is only one eye the cells are stuck up there, depend on the formation of two eyes primarily. Shh mutants mythology of cyclops has an actual foundation (malformed babies/animals/skeletons) Roof plate source of important morphogen, bone morphogenetic protein (bmp)
