BIOC 212 Lecture Notes - Lecture 3: Ribonucleoprotein, Glycophorin, Asparagine

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peachdeer29

16 Mar 2012

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Glucocorticoid receptors belong to a family of steroid hormone receptors; respond to hormones by activating/repressing genes in an inflammatory reaction. Ligand binding domain recognizes hormones; dna-binding domain binds to gr promoter elements gre --> Usually bind only hsp90; are adaptors that connect chaperones to different protein complexes/locations. Gr lbd hydrophobic steroid is bound in the interior of the lbd (ligand-binding domain); necessary to maintain native state; without corticosteroids, lbd can"t fold stably. Chaperones keep lbd partially folded so it can bind hormones; other domains of gr remain folded. Sequential action of chaperones lbd is folded by a defined sequence of chaperones: Without hormone, gr continues to cycle through the system; with hormone gr becomes a stable dimer. Hsfi is a transcription factor, regulator of the heat shock response. Has dna-binding, transcription activation and trimerization domains. Inactive hsfi is a monomer; active it is a trimer and recognizes hse (heat shock element) promoters.

Related Questions

Which pituitary cell is primarily under inhibitory control from the hypothalamus?

Thyroid hormone receptors

A) are frequently dimerized with retinoid X receptor

B) complex with chaperone proteins when no hormone is bound

C) have higher affinity for T4 than for T3

D) are coupled with Ga-s proteins

E) A and B are correct

2. The receptor that binds the steroid hormone testosterone is located in the cytoplasm of its target cells. Vasopressin is a peptide hormone (nine amino acids long) that stimulates water reabsorption in the kidney. Its receptor is an integral protein in which the domain of the receptor responsible for binding vasopressin is located on the extracellular side of the cell membrane.

a) Why must the vasopressin-binding domain of the vasopressin receptor be located on the outside of a cell while the testosterone receptor can be located within a cell? Neither hormone binds to another molecule before it binds to its receptor. (If you are curious, the vasopressin sequence is Gly-Arg-Pro-Cys-Asn-Gln-Phe-Tyr-Cys â you can look up those side chains if you want.)

b) What type or types of amino acids do you expect to predominate in the vasopressin-binding domain of the vasopressin receptor? What type or types of amino acids do you expect to find the transmembrane region of the vasopressin receptor (this region has several alpha helices passing through the membrane)? Explain your reasoning.

c) Why are alpha-helices commonly found in the transmembrane region of integral proteins?

crimsonbear193

A DNA- binding protein called a ___________ binds at a site in DNA called a ____________. These proteins may include a _______ hormone bound to a receptor. This receptor includes a ________ domain that permits movement of the hormone receptor complex through a ___________ into the nucleus so that the hormone receptor complex can bind to _______. The transactivation domain is located nearest to the _________ terminus of the hormone receptor and helps provide access by the nuclear enzyme ________ that transcribe the ______ in the DNA.

BIOC 212 Lecture Notes - Lecture 3: Ribonucleoprotein, Glycophorin, Asparagine

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