BIOC 212 Lecture Notes - Lecture 23: Talin Protein, Salt Bridge, Integrin
14 Oct 2015
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Document Summary
Integrin activation outside in: regulated via extracellular ligand binding, conformational change, straightening from bend conformation, separation of the cytoplasmic domains. Takagi j (2002) cell, 110, 599-611 and hynes ro (2002) cell, 110, 673-687. Basement membrane = basal lamina, sheet-like structures. Separation of epithelial and endothelial cells from connective tissue. Surround cardiac, smooth and skeletal muscle, adipocytes, Influence cell proliferation, adhesion, migration, differentiation, polarization. Development, tissue maintenance, regeneration and repair, pathological processes. Reservoir for growth factors, enzymes and plasma proteins. Receptor mediated laminin polymerization: laminin binds on cell surface via 1 integrins and ds, anchored through its g domain, l. conc. on cell surface polymerize through its short arms, creating a network. N engl j med 348:2543-56 (2003) and jbc (1993) Assembly of collagen type iv: 3 nc1 domains initiate interaction, dimer formation between 2 protomers, 4 protomers interact at the glycosy- lated 7s region to form tetramers. Adapter protein between col iv and laminin.
