BIOC 311 Lecture Notes - Lecture 28: Lysine, Missense Mutation, Western Pattern Diet
18 Jun 2016
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Lecture 28: plp enzymes mercredi 11 novembre 2015. Nitrogen cycle: nitrogen is the source of amino acids required for your body to perform biological functions. Natural nitrogen fixation (1) lightning (high t) and (2) microorganisms, bacteria able to break down nitrogen triple bond (large number of atp required) N assimilation: synthesis glutamine, glutamate and synthesis of carbomoyl phosphate. Transamination: transfer alpha amino group of aa onto a-kga and generate glutamate (only one that undergo oxidative deamination under reasonable rate) Glutamine is used for synthesis of n-containing compounds. Difference: alpha amino group is replaced by carboxyl group (keto group) => deamination. Conversely, you can attached amino group onto keto-acid and becomes amino acid => animation. Catalyzed by amino-transferase, transfer amino group of amino acid onto alpha- ketoglutarate forming glutamate and generating alpha-keto acid matching to the amino acid. We see an enzyme preference to alpha-ketoglutarate as the acceptor of the amino group leading to funnelling and production of glutamate.
