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Class Notes for Biotechnology at McGill University

BIOT 505 Lecture Notes - Lecture 1: Paul Wiseman, Crispr, Biological Engineering
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01.BIOT 505: Selected Topics in Biotechnology 9 September 2016 What is biotechnology? o Must develop a product in order to have a biotechnology. Otherw ise it would just be research. o Technology involving the use of biolo...

Biotechnology
BIOT 505
Jacalyn Vogel
BIOT 505 Lecture Notes - Lecture 2: Hematopoietic Stem Cell, Zinc Finger, Bone Marrow
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02. BIOT 505. Selected Topics in Biotechnology Nontransgenic, i.e. bone marrow Versus transgenic Mouse is the most important animal in stem cell research IPS technology Fuse mouse and human embryo 2013, introduced CRISPR C...

Biotechnology
BIOT 505
Jacalyn Vogel
BIOT 505 Lecture Notes - Lecture 5: Artificial Kidney, Nanobiotechnology, Nanomedicine
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05.BIOT 505 . Selected Topics in Biotechnology Artificial Cells Note that the purpose of artificial cells is not to reproduce biological cells. Cell culture is better!! Basic principles: o First model with ultrathin polyme...

Biotechnology
BIOT 505
Jacalyn Vogel
BIOT 505 Lecture Notes - Lecture 9: Christmas Bird Count, Galaxy Zoo, Comparative Genomics
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-MSA into puzzle: Result hep make better alignment of genomes. Help improve the alignment -Citizen science/crowdsourcing/human-computing: developing application to involve people into real research. Terms may overlap but...

Biotechnology
BIOT 505
Elias Georges
BIOT 505 Lecture Notes - Lecture 8: Nitrogen Fixation, Root Nodule, Genistein
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Signaling Between Plants and the Phytomicrobiome EXPLOITATION FOR IMPRROVED CROP GOWTH Donald L. Smith Nitrogen is Important After carbon, O2 and hydrogen, it is the most abundant element in living systems. Used in port...

Biotechnology
BIOT 505
Elias Georges
BIOT 505 Lecture Notes - Lecture 7: International Practical Shooting Confederation, Clinical Endpoint, Drug Discovery
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Coming full circle into phenotypic drug discovery -Failure of new drug discovery pipeline has led to in vivo phenotypic screens (which was popular in 1900s) -Drug discovery is harder now, targets are more difficult. Als...

Biotechnology
BIOT 505
Elias Georges
BIOT 505 Lecture Notes - Lecture 6: Equilibrium Constant, Total Internal Reflection Fluorescence Microscope, Fluorometer
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Label-free Analysis of Biomolecules Mark A. Hancock (Biochemist) AIM: How was they interact, how strong/weak are those interactions. 1. Protein Interaction (Networks) The study of biomolecules is critical for unders...

Biotechnology
BIOT 505
Elias Georges
BIOT 505 Lecture Notes - Lecture 5: Phenylalanine Ammonia-Lyase, Hemoperfusion, Acatalasia
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Introduction Why reproduce biological cell when can have cell culture. AIM: Use the principle to go outside the box to innovate. Dont need to put enzyme inside cell can put cell inside cell. If really go outside the bo...

Biotechnology
BIOT 505
Elias Georges
BIOT 505 Lecture Notes - Lecture 1: X-Ray Crystallography, Radionuclide, Multiple Sclerosis
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Lecture 1: Course introduction/ Protein interactions and biomarker discovery Elias Georges What is Biotechnology o A technology involving the use of biologic organism (micro), biomolecules (protein/DNA), extracts ...

Biotechnology
BIOT 505
Elias Georges

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