CHEM 182 Lecture Notes - Acromegaly, Peptic Ulcer, Progestin
11 Mar 2014
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Brown-sequard (1889)- injected himself with macerated dog testicles, then monkeys. (sherlock. Holmes author sir arthur conan doyle didn"t like this man"s ethics on animals- the adventure of the creeping man story)- introduced the idea of hormone therapy. Product sequarin (supposed to be extract of testes) made several years after his death. John romulus brinkley (time of brown-sequard)-saw business opportunity, bought himself a medical degree (only needed money and a short fellowship), started a business=goat to man testicle transplant (1700 in career, never connected it to anything in body ). 1895-adrenalin extract injected to raise blood pressure-works, still used (epipen) Fed animal food, injected ground duodenum into jugular. - thought something from duodenum was released into bloodstream that caused message to be sent to release digestive juices from pancreas and liver. Chemical/the something given term secretin- first hormone to be completely purified (a peptide). Kidneys secrete hormones maintaining mineral balance within the body.
