September 13, 2011
Chemistry of Drugs – Lecture 2: Pain Relievers (Analgesics)
~$25 billion on OTC drugs
o Highest: cough and cold
o Followed by: pain relievers, antacids, oral antiseptic, laxatives.
Safety of OTC:
o Indications and counter indications
Pain relief: ~$3 billion. 50 billion tablets/year in North America
Most widely-used worldwide is Aspirin: 50 billion tablets/year Worldwide. 25000
research papers on Aspirin.
Salix (salicylates) family: Willow tree, poplar, beech, wintergreen
o Willow leaves used in 2,200 BC for joint pain by Sumerians (wound