FDSC 537 Lecture Notes - Lecture 7: Adipose Tissue, Coagulation, Cell Adhesion Molecule
25 Oct 2018
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Midterm 1: unit 1 and 2 (2 part: toxic material from food + inflammation) Unbalanced diet (too little fruit and vegetable, polyphenol and other ao) Thus increasing risk of inflammatory response ---becoming chronic. Infiltration of inflammatory cell into adipose tissue ---->obesity. Glycoprotein produced by immune cell + vascular cell. Cell adhesion molecule (cam): help migration of leucocyte toward inflammatory site + interact with inflammatory cell. Evasion of apoptosis of cancer cell lead to carcinogenesis + tumor progression. Cox2, pge2, camp: suppress apoptosis / stop apoptosis. Release ros + pro inflammatory cytokine which damage the neuron. Increased conc of glu + fa in skeletal muscle, liver, adipose tissue lead to metabolic disorder. Mechanism of inflammation associated pathogenesis in rheumatoid arthritis & osteoporosis. Activate synovial fibroblast (cell for syn of collagen) + produce protease (lead to tissue destruction) Convert ang into ang i-->ang ii to regulate bp. Start with activation of endothelium + monocyte transmigration.
