FDSC 537 Lecture Notes - Lecture 6: Amadori Rearrangement, Maillard Reaction, Rheumatoid Arthritis
25 Oct 2018
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They stimulate release of second-phase cytokine / chemokine (il6, il8) Chronic inflammation: subsequent reaction may occur when stimulus can"t be removed progressed chronic illness by infiltration of inflammatory cell, excess cytokine and dis-regulation of cellular signaling. Inflict more serious damage to host tissue than bacterial infection. 3. signaling molecules inflammatory gene expression and activation of enzymes involved in chronic inflammation. Inflammatory chemical also attack normal tissue surrounding the infected tissue. Increase of neutrophil (wbc) (1st responder) + inflammatory mediator (cid:894)(cid:272)(cid:455)toki(cid:374)e, (cid:272)he(cid:373)oki(cid:374)e, phago(cid:272)(cid:455)tosis (cid:895) Glucosone: reactive carbonyl produced by amadori compound of glucose. This also happen inside the body (takes yr to happen) ex. Age: advanced glycation end products / lipoxidation end product - ale - glycotoxin. Due to maillard reaction; end product of ros. E(cid:454). dia(cid:271)etes, alzhei(cid:373)er"s disease, amd (cid:894)age-related macular degeneration ) Produced from heated food ---metabolically activated into alkylating agent of dna. Conc dependent issue (eat more, have more acrylamide)
