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Lecture 3

Lecture 3 (revised) .docx

40 Pages
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Department
Kinesiology&Physical Education
Course Code
EDKP 395
Professor
Russell T Hepple

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Kreb Cycle 10/20/2012 7:43:00 AM AKA citric acid cycle Invented by Hans Krebs o Rejected the first 2x he presented his theory Main function is to remove hydrogen and associated energy bond b/w hydrogen and various substrates involved in kreb cycle o H+ contain the PE in food molecules Enzymes found in mitochondrial matrix citrate synthase enzyme o Electron transport is found in cortex OCCURS in mitochondria Occurs ANAEROBICALLY but the formation of ATP from the kreb cycle requires the use of O2 O2 Is the last electron acceptor of kreb cycle (i.e. before ETC) o This makes is an aerobic method of ATP production i.e. oxidative phosphorylation Process o Pyruvic acid (3C) is converted to acetyl-CoA (2C) CO2 is produced o Acetyl-CoA combines with oxaloacetate (4C) to form citrate (6C) Enzyme citrate synthase catalyzes this event o Citrate is metabolized into oxaloacetate Two CO2 molecules produced cyclic procedure due to reformation of oxaloacetate Products during EACH kreb cycle o 3 molecules of NADH contributes the most amount of energy 2.5 ATPs formed formed at 3 different places isocitrate isocitrate dehydrogenase alpha ketoglutarate alpha ketoglutarate alpha keto. Dehydrogenase succinyl-CoA malate malate dehydrogenase oxaloacetate o 1 molecule FADH2 contribute 2nd most amount of energy 1.5 ATPs formed for 1 FADH molecule NADH >>> FADH2 in terms of richness of energy (how many ATPs form from 1 molecule) Formed during 1 step Succinate succ. Dehydro. fumarate o 1 molecule GTP formation is called substrate-level phosphorylation high energy compound transfer terminal phosphate group to ADP to form ATP By product is 3 molecules of CO2 Note: if talking about products produced from kreb cycle AFTER glycolysis, remember that for every 1 glycolysis there are 2 kreb cycles Image depicts the 3 products that are formed during kreb cycle Oxidative Phosphorylation is required to occur first in order to produce Acetyl-CoA 3 stages of oxidative phosphorylation 1. Primary pathway: aerobic (must be in the presence of O2) Glycolysis pyruvate acetyl-CoA o Glycolysis produces 2 pyruvate molecules
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