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Lecture 5

Lecture 5 (revised).docx

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McGill University
Kinesiology&Physical Education
EDKP 395
Russell T Hepple

Structures 10/31/2012 9:23:00 AM Skeletal muscle >600 skeletal muscles o 40-50% of body weight Function o Force production of locomotion and breathing o Force production for postural support o Heart production during cold stress Muscle loss in a variety of medical conditions is important Structure o Myofibrils Located under sarcoplasmic reticulum Contractile part of muscle (contain contractile proteins) Myosin- thick Actin- thin characterstic of developing muscle o Muscle fibers Multinucleated striated o Fasicle Individuals bundles of musle fibers o Fascia Separate muscles from one another Hold muscles in position Satellite cell o Located near periphery Above sarcolemma (fiber membrane), below external lamina o Derived from Bone marrow From regenerative cells o Pleuripotent undifferentiated Can become many different types of cells (bone marrow, adipose tissue, RBC) Expected fate is muscle cells/muscle fibers o Important for muscle growth/regeneration/recovery from injury o Myotically active satellite cells Cells that are undergoing proliferation on the outside of the cell They fused w/ membrane and head towards center of muscle to take over reparations Keeps the cell volume per nucleus constant Sarcoplasmic reticulum o Wound around myofibrils o Channels that allow for conduction of AP resulting in Na+/Ca++ fluxes in the vicinity of mitochondria o Store Ca++ Transverse Tubules o Extend from sarcolemma through fiber o
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