EDKP 485 Lecture Notes - Lecture 20: Hypotension, Vasoconstriction, Acidosis

• School: McGill University
• Department: Kinesiology and Physical Ed
• Course: EDKP 485
• Professor: Dennis Jensen

Document Summary

Acute exercise physiological responses - exercise pathophysiology of heart failure chf. Relationship between v"o2peak & survival in hf in 3 year follow-up. Greater survival = risk of death. Lower survival = risk of death. Strong relationship between exercise tolerance & survival. *chf patients vs healthy = impaired exercise tolerance. 1- v"o2 = oxygen consumption *measure of oxidative phosphorylation: shallower v"o2/ wr slope. Peak vo2max & peak wrmax so reliance on non-oxidative anaerobic processes. 2- v"co2 = co2 production *reflect metabolic acidosis: higher v"co2/ wr slope. Rate of co2 production due to buffering of acidosis. Higher rate of acidosis = since reliance on anaerobic glycolytic. Due to inadequate o2 delivery since impaired sv / co / blood flow. & result in rer / more distressed muscle / more metabolic stress so ventilation. 3- rer = respiratory exchange ratio *reflect . *since v"co2/wr response & v"o2/wr response = rer: higher rer/ wr slope.