LSCI 211 Lecture Notes - Lecture 13: Nadh Dehydrogenase, Superoxide Dismutase, Succinate Dehydrogenase
28 Aug 2016
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Oxidation of glucose or fatty acids provide much more energy than fermentation. Oxygen is the terminal electron acceptor (from nadh and fadh2) Oxygen is reactive and makes toxic intermediates through oxidation. High energy electrons extracted from carbon sources (glucose, fatty acids) Added to nadh and fadh2, and transported to oxygen through the etc. Chemical energy is generated, a proton gradient is created. Etc is located on the inner membrane of the mitochondria. E"0 for electron transfer from nadh to oxygen is +1. 14v. Complexes take on electrons and pump protons through the membrane. 2e- from 1 nadh: fmn 7 fe-s clusters coenzyme q. 4 h+ pumped into the intermembrane by the quinone. E- passed to coenzyme q (uq) for transfer to complex 3. Cyt bh , bl cyt c1, fe is reduced in the fe-s cluster. Cyt c cua/cub cyt a heme a3 o2 bound, then broken fe-cu centre. 4e- (from 2 nadh) per o2 consumed (converted to water)
