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Lecture 26

MIMM 214 Lecture 26: Antibodies

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McGill University
Microbiology and Immun (Sci)
MIMM 214
Claire Trottier

Lecture 26 Monday, February 20, 2017 1:04 PM Antibodies are glycoproteins 2 identical heavy, 2 identical light chains Heavy (H) chains ar isulfidelinked 4 Iglike domains 4 chains total Note: theres variable region in BOTH light heavy chains Both light heavy hav onstant regionas well VL variable region of light chain VH variable region of heavy chain Antibody binding can do neutralization (to prevent virus from infecting host cell; or to prevent pathogen from being functional), but NOT ALWAYS neutralization Constant region: Complement binding Can bind to receptors on different cell types Papain: an enzyme that cleaves the antibody; cuts it near the disulphide bond right across middle of the Y: resulting in cut antibody in 3 FRAGMENTS 2 Fab fragments : with identical Ag binding sites 1 Fc fragment Fc fragment: Fc bc crystalizable Receptors that bind antibodies bind the Fc region
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