MIMM 387 Lecture : jan 30 2012- murgita.docx
15 May 2012
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Novel molecular strategies for the prevention of anogenital cancers. Anogenital cancers affect men and women, but cervical cancer is the most important. It is most important in 3rd world countries because they do not have well-established ways to deal with these cancers. Can infect the genital tracts of men and women. Types that cause cancer are high-risk genotypes, as opposed to low-risk genotypes. There are 12 hpv genotypes considered oncogenic; several others are still under investigation. They are probably also oncogenic, but they are so rare it is hard to show if they are oncogenic or not. In vitro evidence that the virus can change and immortalize cells (over express the gene); but this is not a clear demonstration that it causes disease in humans. This is better for showing how the virus causes disease . To implicate the virus in cancer, you need to do epidemiological tests.
