MIMM 413 Lecture : feb 8 2012- dr. shio.docx

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magentacricket108

15 May 2012

School

McGill University

Department

Microbiology and Immun (Sci)

Course

MIMM 413

Professor

Various

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Document Summary

Marsh disease: because of the association of the disease with marshes. Once they form the vacuole, they start to multiply, and they form the schizont. After the schizont form, it escapes from the hepatocyte into the merozoite formation. Then it is released to the blood system. Erythrocyte binding antigen and duff-binding antigen are important for infection of rbc. Attachment and junction formation is mediated by attachment of different compounds based on the parasite. After the ring form matures it becomes the trophozoite (there is also formation of the food vacuole, where you have the formation of the hemozoin). Heme is toxic for the parasite, so the parasite removed it by polymerizing it to form hemozoin crystals that have a brownish colour. After you have more division of the parasite, you have the schizont. Then there is rupture of the rbc and release of the merozoites. Malaria becomes sexually reproductive once warm human blood cools in the mosquito.

Related Questions

1. Fill in the words or phrases that best complete each sentence. Be as specific as possible.

a. Erythrocytes contain the enzyme -------- , which catalyzes the conversion of metabolically produced CO₂ and water into --------- .

b. Most old erythrocytes are removed from circulation and destroyed by cells called ------------- , as they rupture passing through the narrow capillaries of the organ called the --------- .

c. Undifferentiated cells called------------ reside in the bone marrow, where they continuously divide and-------------- to give rise to each of the types of blood cells.

d. The process of leukocytes squeezing through the capillary ----------- to exit the vasculature is known as ----------- . Once they leave the bloodstream to fight a pathological condition, they never return.

e. The genetically-determined glycoprotein and glycolipid antigens found on the surface of an erythrocyte are called-------------- , and a person with agglutinins that react with type A and blood type B has type------------- blood.

f. During embryonic development, ninety-nine percent of the cardiac fibers are specialized for the function called----------- , whereas the remainder is specialized for-------------- .

g. The action potential delay at the-------------------- ensures that atrial excitation and contraction are complete before------------------ excitation and contraction commence.

h. The--------------------- is the volume of blood in the ventricle after ejection has been completed. An increase of this volume occurs when the stroke volume is .

i. The three cations, K⁺, Ca²⁺, and Na⁺ have an important effect of heart function. Increased blood levels of Na⁺ blocks----------------- inflow and results in a decrease in the force of contraction, while an excess of---------------- blocks the generation of action potentials.

j. An increase in parasympathetic activity ---------------- has the following effect on stroke volume: ---------------- . An increase in parasympathetic activity --------------- atrial contractility.

A 27 year old Hispanic male with a frequent history of opiate abuse arrives in the emergency room short of breath and complaining of intense generalized abdominal pain. Pulse Ox is 88%, mucous membranes are pale. He states a family history of this condition which affects him and his sister intermittently. Auscultation of the lungs reveals lower right lobe consolidation and hepatosplenomegally. A blood smear reveals enlarged, pale erythrocytes of which approximately 20% have an unusual curved and flattened shape.

It appears the erythrocytes have lost their normal biconcave shape due to stressors (such as low serum pO2 levels)on the patient. Which of the following does not apply to this patientâs condition?

a. Patient may have inherited a genetic mutation that results in unstable hemoglobin proteins.

b.Abdominal pain is likely due to multiple microscopic thrombi causing ischemia and infarcts.

c.Patient should be offered oxygen and opiates immediately.

d. This patient is immune to malaria.

e.This patient has increased susceptibility to infection due to abnormally low antibody production.

hello , please answer all the question with datails

1- What are immature red blood cells containing filaments that stain with basic dye called? When would we see increased numbers of these cells?

2-Why are normal erythrocyte and hemoglobin levels important in blood?

3-When considering the leukocytes categorized as granulocytes, what is the correlation between their name and the color of their granules?

4- You have a patient with a productive cough, producing rusty-brown mucus. They are febrile and are having chills and night sweats. You order a blood analysis and note that their leukocyte count is above 10,000 per Î¼l of blood .with neutrophils numbers greatly increased . In considering the possible type of infection, what would you say is the most likely infactions agent and why

MIMM 413 Lecture : feb 8 2012- dr. shio.docx

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